HCID 21273564, compound → HCID 21273401, compound

HRID 1382927Notes

Reaction equation

HRID 1382927 reaction equation
[ClH:1].[CH2:2]([N:9]([CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[NH:15][C:14]1=[O:22])C)C1C=CC=CC=1>CO.[Pd]>[ClH:1].[CH3:2][NH:9][CH2:11][CH2:12][N:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[NH:15][C:14]1=[O:22]

Participants

4

Reactant 1

HCID 21273564HCID 21273564, compound

Product 1

HCID 21273401HCID 21273401, compoundYield 94.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

22.9 g (72 mmol) of 1-[2-(N-benzyl-N-methylamino)ethyl]-2-benzimidazolinone hydrochloride are dissolved in 250 ml of methanol, treated with 2.5 g of palladium-on-carbon (10%) and hydrogenated at room temperature for 90 minutes. The residue obtained after filtration and concentration is recrystallized from methanol/ether, whereby there are obtained 15.5 g (94%) of 1-[2-(methylamino)ethyl]-2-benzimidazolinone hydrochloride, m.p. 177°-180°.

Workup

  1. customThe residue obtained
  2. filtrationafter filtration and concentration
  3. customis recrystallized from methanol/ether, whereby there

Sources & evidence

ORD record
ord-43ff772750504afb9397b9c4dd6719fe
Source dataset
uspto-grants-1989_02
Patent number
US04808605

Reaction notes

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