HCID 178484003, compound → HCID 178484002, compound

Participants

Reaction Steps

6.0 g of benzyl [[trans-4-(2-benzimidazolyl)cyclohexyl]methyl]methylcarbamate are dissolved in 600 ml of ethanol and hydrogenated at room temperature and normal pressure after the addition of 1 g of 5% palladium-on-active charcoal. The product, isolated in the usual manner, is recrystallized from methylene chloride/ether. There are obtained 3.0 g (78%) of 2-[trans-4-[(methylamino)methyl]cyclohexyl]benzimidazole, m.p. 232°-235°, as a colourless crystalline powder.

Provenance & Evidence