HCID 178484001, compound → HCID 178484000, compound

Participants

Reaction Steps

5.9 g of benzyl [[trans-4-(1-methyl-2-benzimidazolyl)cyclohexyl]methyl]methylcarbamate are dissolved in 600 ml of ethanol and hydrogenated at room temperature and normal pressure after the addition of 1 g of 5% palladium-on-active charcoal. The product. isolated in the usual manner, is chromatographed on 250 g of silica gel firstly with methylene chloride/methanol (1:1) and then with methanol/concentrated ammonium hydroxide (100:1) as the elution agent. There are obtained 3.3 g (85%) of 2-[trans-4-[(methylamino)methyl]cyclohexyl]-1-methyl-benzimidazole as a thick oil.

Provenance & Evidence