Hydrochloric Acid → HCID 14372132, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-sulfamoyl-4-chloro-furo[3,2-c]pyridine (1.02 g, 4.4 mmol) in 2-(dimethylamino)ethylamine (1.4 ml, 12.8 mmol) was warmed at 90° C. for 8 hours. The cooled mixture was diluted with water and made basic with saturated sodium carbonate. The product was extracted into ethyl acetate/methanol, dried over anhydrous sodium sulfate, and filtered. The solution was evaporated to give crude product. This residue was dissolved in methanol and excess ethanolic HCl was added. After dilution with diethyl ether, the resultant gum was digested in ethanol to give a powder (0.86 g, 55% yield), mp: 275°-278° C. Recrystallization of this salt by dissolution in a minimum amount of warm water and subsequent dilution with ethanol gave pure dihyrochloride salt (0.56 g) mp: 281°-283° C.

Provenance & Evidence