Hydrochloric Acid → Furo[2,3-b]pyridine-2,5-dicarboxylic acid

Participants

Reaction Conditions

Reaction Steps

A suspension of diethyl furo[2,3-b]pyridine-2,5-dicarboxylate (10.5 g, 40 mmol) in 1N sodium hydroxide (100 mL) was warmed at 70° C. for two hours. The cooled solution was acidified with conc. hydrochloric acid and the precipitate was collected by filtration and successively washed with water, ethanol and diethyl ether to give pure product (8.14 g, 98.5% yield) mp: >315° C.

Provenance & Evidence