Hydrochloric Acid → HCID 70392841, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of N,N-dimethyl-N'-[6-methyl-5-oxido-furo[3,2-c]pyridine-2-sulfonyl]formamidine (4.24 g, 15 mmol) (from Example 13, Step B) in acetic anhydride (13 mL), under a nitrogen atmosphere was heated at 140° C. for 20 minutes to give an amber solution. This reaction mixture was cooled to 100° C. and 6% hydrochloric acid (30 mL) was added. After stirring at 100° C. for 4 hours, the reaction mixture was poured into saturated sodium carbonate (~100 mL) carefully. The product was extracted into methylene chloride, dried over anhydrous sodium sulfate, filtered through a charcoal pad and evaporated to dryness. This residue was triturated with diethyl ether/methylene chloride to give the product (2.21 g, 52% yield) which was used as is.

Provenance & Evidence