4-Nitro-2,2'-bipyridine-N-oxide → HCID 178507919, compound

A suspension of 2.6 grams (0.012 mole) of 4-nitro-2-(2-pyridinyl)pyridine-N oxide and 0.42 gram of 10% palladium on charcoal in 10 ml of water and 200 ml of ethanol was hydrogenated using a Parr hydrogenator. Upon completion of hydrogenation the reaction mixture was purged with nitrogen gas for one hour, then concentrated under reduced pressure to a residual solid. The solid was triturated with 200 ml of water. The mixture was filtered and the filter cake washed with water. The combined filtrate and wash were concentrated under reduced pressure to a residue. The residue was taken up in 30 ml of ethanol and concentrated under reduced pressure. This procedure was repeated three additional times to remove residual water. The residue was dried under reduced pressure at 60° C. to yield 1.9 grams of 4-amino-2-(2-pyridinyl)pyridine-N oxide as a solid. The nmr spectrum was consistent with the proposed structure.

1. customUpon completion of hydrogenation the reaction mixture was purged with nitrogen gas for one hour
2. concentrationconcentrated under reduced pressure to a residual solid
3. customThe solid was triturated with 200 ml of water
4. filtrationThe mixture was filtered
5. washthe filter cake washed with water
6. washThe combined filtrate and wash
7. concentrationwere concentrated under reduced pressure to a residue
8. concentrationconcentrated under reduced pressure
9. customto remove residual water
10. customThe residue was dried under reduced pressure at 60° C.

ORD record

ord-b381dfe441514683910d080b9523bbde

Source dataset

uspto-grants-1989_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04808722