1-Chloro-2,4-Dinitrobenzene → 5-Nitro-1,3-benzothiazol-2-amine

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Reaction Steps

A solution of 10.13 g of 2,4-dinitrochlorobenzene and 15.2 g of thiourea in 50 ml of pyridine is boiled, with stirring, under a reflux condenser for 3 hours. After cooling, the mixture is thoroughly stirred with 500 ml of water, and the solid is filtered off with suction, washed with water and dried. 11.6 g of 2-amino-5-nitrobenzothiazole having a purity of 66% by HPLC analysis, corresponding to a yield of 78.5% of theory, are obtained.

Provenance & Evidence