4-Chloro-3,5-dinitrobenzotrifluoride → HCID 14928315, compound

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Reaction Conditions

Reaction Steps

67.5 g of 4-chloro-3,5-dinitrobenzotrifluoride are slowly introduced, with stirring, into a solution of 76 g of thiourea in 250 ml of sulpholane at 100° C. The mixture is stirred at 100° C. for a further one hour. After cooling, the precipitate is filtered off with suction and dried. 35.7 g of crude 2-amino-5-trifluoromethyl-7-nitrobenzothiazole of melting point 254°-256° C. (decomposition) are obtained. Recrystallisation from pyridine/water (3/1) raises the melting point to 262°-263° C. me+ : 263.

Provenance & Evidence