HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-4-Fluoro-3-phenoxybenzaldehyde-cyanhydrine → (S)alpha-cyano-3-phenoxy-4-fluoro-benzyl (1R,cis,E) 2,2-dimethyl-3-[2-fluoro-3-oxo-3-(1,1-dimethyl-ethoxy)-1-propenyl]-cyclopropanecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-4-Fluoro-3-phenoxybenzaldehyde-cyanhydrine | HCID 12803645 | — |
| Reactant | (1R,cis,E) 2,2-dimethyl-3-[2-fluoro-3-oxo-3-(1,1-dimethyl-ethoxy)-1-propenyl]-cyclopropane carboxylic acid | HCID 13372597 | — |
| Product | (S)alpha-cyano-3-phenoxy-4-fluoro-benzyl (1R,cis,E) 2,2-dimethyl-3-[2-fluoro-3-oxo-3-(1,1-dimethyl-ethoxy)-1-propenyl]-cyclopropanecarboxylate | HCID 13372614 | — |
Reaction Steps
Using the procedure of Step B of Example 43, (1R,cis,E) 2,2-dimethyl-3-[2-fluoro-3-oxo-3-(1,1-dimethyl-ethoxy)-1-propenyl]-cyclopropane carboxylic acid and (S)α-cyano-3-phenoxy-4-fluoro-benzyl alcohol were reacted to obtain (S)α-cyano-3-phenoxy-4-fluoro-benzyl (1R,cis,E) 2,2-dimethyl-3-[2-fluoro-3-oxo-3-(1,1-dimethyl-ethoxy)-1-propenyl]-cyclopropanecarboxylate melting at 122° and having a specific rotation of [α]D20 =+61°±2.5° (c=0.35% in chloroform).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04808749 |
| Source dataset | uspto-grants-1989_02 |
| ORD ID | ord-42c1eafef2c344438e262ad72fbcf5eb |
| Source note | uspto-grants-1989_02 |