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9-Hydroxynonan-2-one → 14-Hydroxy-7-methyltetradec-6-enoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 9-Hydroxynonan-2-one | HCID 537408 | — |
| 反応物 | (5-Carboxypentyl)triphenylphosphanium bromide | HCID 2779280 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 14-Hydroxy-7-methyltetradec-6-enoic acid | HCID 86757094 | 111.2% |
反応手順
45.7 g (0.1 mol) of (5-carboxypentyl)triphenylphosphonium bromide were placed in 200 ml of tetrahydrofuran and 25 g (0.22 ol) of potassium t-butylate in 100 l of tetrahydrofuran were added dropwise at 0° C. Then, 15.8 g (0.1 mol) of 9-hydroxy2-nonanone were added. After stirring for 30 minutes and usual work up, 28.5 g of crude 14-hydroxy-7-methyltetradec-6-enoic acid were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06255276B1 |
| 出典データセット | uspto-grants-2001_07 |
| ORD ID | ord-3f779bc097f5499da2ebb089678870c5 |
| 出典メモ | uspto-grants-2001_07 |