3-Chloro-1,2-propanediol → HCID 54385380, compound

Participants

Reaction Steps

87 g (0.3 mol) of methyl 5Z-6-methylpentadec-5-enoate and 19.5 g of 86 percent potassium hydroxide were dissolved in 200 ml of methanol. 66 g of 3-chloropropane-1,2-diol and 200 ml of glycerol as well as, 5 ml of 5.4M methanolic sodium methylate solution were added. After usual work up the product were distilled in a high vacuum over a Vigreux column. 59 g (78%) of 7-methyloxacyclo-hexadec-6-en-2-one were obtained having the following characteristics: Z/E=56/46;

Provenance & Evidence