Potassium Carbonate → Oxacycloheptadec-8-en-2-one, (8Z)-

Participants

Reaction Steps

41 g of potassium carbonate were suspended in 600 ml of N-methyl-pyrrolidone. A solution of 51 g (0.15 mol) of 7Z-16-bromohexadec-7-enoic acid in 400 ml of N-methylpyrrolidone was added dropwise at 90° C. within 8 hours. After usual work up and chromatography 30 g (77%) of 8Z-oxacycloheptadec-8-en-2-one were obtained having the following characteristics: Z/E=90/10;

Provenance & Evidence