Water → HCID 9824143, compound

Participants

Reaction Steps

A mixture of 1-(2-methoxy-phenyl)-4-piperidin-3-ylmethyl-piperazine (0.5 g, 1.72 mmol) from example 6, 3-(2-bromoethyl)indole (0.38 g, 1 equivalent) and potassium carbonate (0.48 g, 2 equivalents) in acetonitrile (25 mL) were refluxed for 24 hours under a nitrogen atmosphere. Water (100 mL)) was added and the product extracted into ethyl acetate (3×50 mL). The combined organics were washed with water (25 mL), brine (25 mL) and dried over anhydrous sodium sulfate. Filtration and concentration in vacuum afforded the required product. Treatment with excess ethereal HCl gave the hydrochloride salt of the above titled compound as a white solid.

Provenance & Evidence