反应详情

To a solution of 4.3 g of N-acetylimidazole in methanol (100 ml), 5.0 g of 5-chloro-6-chloromethyl-uracil were added, followed by heating for 2 days under reflux. After the reaction mixture was allowed to cool down, a crystallized matter was collected by filtration and then washed with a 10% solution of hydrochloric acid in methanol, whereby 4.32 g of the title compound were obtained (yield: 64%).

1. temperatureby heating for 2 days
2. temperatureunder reflux
3. temperatureto cool down
4. filtrationa crystallized matter was collected by filtration
5. washwashed with a 10% solution of hydrochloric acid in methanol