Bromine → HCID 9860327, compound

HRID 1383347Notes

Reaction equation

HRID 1383347 reaction equation
[N:1]1([CH2:6][C:7]2[NH:12][C:11](=[O:13])[NH:10][C:9](=[O:14])[CH:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:15]Br>C(O)(=O)C>[Br:15][C:8]1[C:9](=[O:14])[NH:10][C:11](=[O:13])[NH:12][C:7]=1[CH2:6][N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 24408BromineHCID 21699317HCID 21699317, compound

Product 1

HCID 9860327HCID 9860327, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of 1.0 g of the 6-(1-pyrrolidinylmethyl)uracil, which had been obtained in Referential Example 7, in acetic acid (10 ml), 1.0 g of bromine was added dropwise, followed by stirring at room temperature for 20 hours. A crystallized matter was collected by filtration and then washed with methanol, whereby 560 mg of the title compound were obtained (yield: 40%). The melting point and NMR spectrum of the thus-obtained compound were in full conformity with those of Compound 2 synthesized by Process A in Example 2.

Workup

  1. filtrationA crystallized matter was collected by filtration
  2. washwashed with methanol

Sources & evidence

ORD record
ord-16c65d0c3412403abfc25c8cf4b3c325
Source dataset
uspto-grants-2001_07
Patent number
US06255314B1

Reaction notes

Loading…