HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → 3-(Formylamino)phenylacetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Ethyl 2-(3-aminophenyl)acetate | HCID 13042040 | — |
| Solvent | Diisopropyl Ether | HCID 7914 | — |
| Product | 3-(Formylamino)phenylacetic acid ethyl ester | HCID 54231628 | 89% |
Reaction Steps
A solution of 3-aminophenylacetic acid ethyl ester (3.0 g; 0.017 mol; from Example T(i) above), and formic acid (1.5 g; 0.034 mol) in diisopropylether (150 mL) was refluxed with a Dean-Stark trap overnight. The solution was concentrated to dryness, dissolved in ether and washed with diluted HCl to remove remaining starting material. Drying (Na2SO4) and concentration yielded the sub-title compound (3.1 g; 89%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06255301B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-b07c10881dcc4af490c8ed2f470936e3 |
| Source note | uspto-grants-2001_07 |