反应详情

A solution of 3-chloro-5-methylphenylacetic acid (5.0 g; 27.09 mmol; from step (iii) above) and H2SO4 (conc.; 0.1 mL) in EtOH (25 mL) was refluxed overnight. The solution was concentrated, and the resultant mixture digerated in Na2CO3 solution (75 mL). After extraction with ether (2×75 mL) the combined organic phases were washed with brine, dried (Na2SO4), and evaporated to yield 4.92 g (85%) of the sub-title compound.

1. concentrationThe solution was concentrated
2. extractionAfter extraction with ether (2×75 mL) the combined organic phases
3. washwere washed with brine
4. dry with materialdried (Na2SO4)
5. customevaporated