HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonyl chloride → HCID 22600111, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | tert-butyl N-(4-chloro-3-(hydroxymethyl)phenyl)carbamate | HCID 54223790 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22600111 | HCID 22600111 | 100% |
Reaction Steps
To an ice cooled solution of 2-chloro-5-(Boc-amino)benzyl alcohol (7.4 g; 29 mmol; from step (i) above) in CH2Cl2 (100 mL) was added TEA (2.9 g; 29 mmol), followed by MsCl (3.3 g, 29 mmol; added dropwise). After stirring for 2 hours the resultant mixture was poured onto water. The organic layer was separated, washed with water, dried (Na2SO4) and concentrated to yield 10 g (100%) of the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06255301B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-3f310dfb18e84bfd841c2b975d707a6b |
| Source note | uspto-grants-2001_07 |