Water → HCID 22600079, compound

Participants

Reaction Steps

A solution of ethyl 2-(4-benzyloxy-3-methoxyphenyl)-3-oxo-propionate (1.356 g; 3.47 mmol; from step (ii) above) in MeOH:CH2Cl2 (3:1, 20 mL) was cooled to −15 to −5° C., and NaBH4 (0.264 g; 6.95 mmol) was added in portions. The cooled reaction mixture was stirred, whereafter it was allowed to attain room temperature. Water was added, and the mixture was partially concentrated. After extraction with EtOAc (2×25 mL), washing of the organic phase with brine, drying (NaSO4) and evaporation, 1.32 g (97.1%) of the sub-title compound was obtained.

Provenance & Evidence