Boron tribromide → HCID 21188009, compound

HRID 1383428Notes

Reaction equation

HRID 1383428 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH:13]=[N:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[N:10]1.B(Br)(Br)Br>ClCCl>[OH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH:13]=[N:12][C:11]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[N:10]1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 9837858HCID 9837858, compound

Product 1

HCID 21188009HCID 21188009, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

1,1 g of 1-(2-methoxyphenyl)-3-phenyl-1,2,4-triazole (cf. Example 2) are dissolved in 40 ml of dichloromethane and a solution of 1 ml of BBr3 in 10 ml of dichloromethane is added dropwise. After 3-4 hours stirring at ambient temperature the mixture is poured onto ice water and the organic phase is separated off. The remaining aqueous phase is again extracted with dichloromethane. After the collected dichloromethane phases have been dried over Na2SO4 the solvent is distilled off. 1 g (96%) of the title compound are left (melting point: 148-154° C.).

Workup

  1. additionis poured onto ice water
  2. customthe organic phase is separated off
  3. extractionThe remaining aqueous phase is again extracted with dichloromethane
  4. dry with materialAfter the collected dichloromethane phases have been dried over Na2SO4 the solvent
  5. distillationis distilled off
  6. wait1 g (96%) of the title compound are left (melting point: 148-154° C.)

Sources & evidence

ORD record
ord-5c7e0919b30842039e6a2257adf490c7
Source dataset
uspto-grants-2001_07
Patent number
US06255327B1

Reaction notes

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