Sodium hydride → HCID 86757109, compound

Participants

Reaction Steps

1.44 g (10 mmol) of 2-phenylimidazole are dissolved in 10 ml of DMF, deprotonated (50° C.) using 330 mg (11 mmol) of NaH (80% strength) and the solution is then treated with 3.5 g (10 mmol) of tert-butyl 4-bromomethyl-2-cyclopentyl-acetate (DE 42 00 954 A1) and stirred overnight at RT. It is concentrated, the residue is dissolved in CH2Cl2, the solution is washed with H2O and concentrated and the residue is chromatographed on silica gel (cyclohexane/EA=8:2).

Provenance & Evidence