Diethyl Ether → HCID 178512294, compound

Participants

Reaction Steps

S-methyl-N-cyano-N′-pyridylisothiourea (3.84 g, 20 mmol) and 1-(2-aminoethyl)piperazine (2.89 ml, 22 mmol) were suspended in pyridine (8 mL) in a reaction flask equipped with magnetic stirring under nitrogen. Triethylamine (2.8 mL, 20 mmol) was added followed by (4-dimethylamino)-pyridine (cat., 100 mg). The reaction mixture became clear. It was stirred at 50-60° C. for 12 hours and cooled to room temperature. Ether (100 mL) was then added and precipitate formed. The precipitate was collected to give crude N-cyano-N′-(2-piperazin-1-yl-ethyl)-N″-pyridin-4-yl-guanidine which was used without further purification. ESMS 274.2 (M+1).

Provenance & Evidence