Hydrazine hydrate (1:1) → HCID 11130710, compound

Participants

Reaction Steps

2-[2-(4-benzhydryloxy-piperidin-1-yl)-ethyl]-isoindole-1,3-dione (0.548 g, 1.24 mmol) was dissolved in ethanol (2 ml), followed by the addition of hydrazine hydrate (large excess, 2-3 ml). The solution was refluxed for 2 hours. The white solid was precipitated. After cooling to the room temperature, the white solid was filtered off and washed with small amount of ethanol. The filtrates were combined and concentrated. The resulted residue was dissolved in toluene (100 ml). The solution was washed with water (3×20 ml) and dried over anhydrous Na2SO4. After evaporated the solvent, the crude product, 2-(4-benzhydryloxy-piperidin-1-yl)-ethylamine was obtained (0.326 g, 84.4% yield). 1H-NMR (CD3OD, ppm): 7.15-7.40 (m, 10H), 5.58 (s, 1H), 3.46 (m, 1H), 2.77 (m, 2H), 2.72 (t, 2H), 2.40 (t, 2H), 2.18 (m, 2H), 1.89 (m, 2H), 1.70 (m, 2H). ESMS 311.2 (M+1), 333.2 (M+23).

Provenance & Evidence