Sodium Iodide → HCID 10928314, compound

Participants

Reaction Steps

The mixture of 1-(diphenylmethyl)piperazine (505 mg, 2 mmol, 1.0 eq.), N-(2-bromoethyl)phthalimide (508 mg, 2 mmol, 1.0 eq.), K2CO3 (415 g, 3 mmol, 1.5 eq.), and NaI (420 g, 2.8 mmol, 1.4 eq.) in 2-butanone (10 ml) was refluxed for 2-3 hours. The mixture was then cooled to room temperature. The white solid was filtered off and was washed with small amount of CHCl3. The filtrates were combined and concentrated. The resulted residue was dissolved in CHCl3 (100 ml). The solution was washed with water (3×10 ml), then dried over anhydrous Na2SO4. After removed all solvent, the crude product 2-[3-(4-benzhydryl-piperazin-1-yl)-propyl]-isoindole-1,3-dione was yielded (935 mg, 110% yield).

Provenance & Evidence