Methanol → HCID 21188125, compound

Participants

Reaction Steps

To a stirred solution of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)4-(3-hydroxyprop-1-ynyl)pyrazole (250 mg, the compound of Example A6) in ether (10 ml) was added manganese dioxide (1 g) and the mixture stirred at room temperature for two hours. Methanol (2 ml) and potassium cyanide (250 mg) were then added and stirring continued for 15 minutes. The reaction mixture was filtered and evaporated to dryness. The residue was purified by chromatography on silica gel eluted with dichloromethane. Combination and evaporation of appropriate fractions provided the title compound as a light brown solid m.p. 201-2° C.

Provenance & Evidence