Acetyl chloride → HCID 21188114, compound

HRID 1383572Notes

Reaction equation

HRID 1383572 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]#[N:20])[C:3]=1[I:21].[C:22](Cl)(=[O:24])[CH3:23]>N1C=CC=CC=1>[C:22]([NH:1][C:2]1[N:6]([C:7]2[C:8]([Cl:18])=[CH:9][C:10]([C:14]([F:17])([F:15])[F:16])=[CH:11][C:12]=2[Cl:13])[N:5]=[C:4]([C:19]#[N:20])[C:3]=1[I:21])(=[O:24])[CH3:23]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 154620775-Amino-3-cyano-4-iodo-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]pyrazole

Product 1

HCID 21188114HCID 21188114, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a stirred solution of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-iodopyrazole (447 mg, the compound of Example A1) in pyridine (5ml) was added dropwise acetyl chloride (0.5 ml). The reaction mixture was stirred at room temperature for 2 days and then heated at 50° C. for 4 hours. The reaction mixture was partitioned between ether (50 ml) and water (50ml), the organic layer was separated, dried (MgSO4) and evaporated.

Workup

  1. temperatureheated at 50° C. for 4 hours
  2. customThe reaction mixture was partitioned between ether (50 ml) and water (50ml)
  3. customthe organic layer was separated
  4. dry with materialdried (MgSO4)
  5. customevaporated

Sources & evidence

ORD record
ord-0c108a53ae764222b6e1708c3ad52f51
Source dataset
uspto-grants-2001_07
Patent number
US06255333B1

Reaction notes

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