Water → HCID 21188077, compound

HRID 1383573Notes

Reaction equation

HRID 1383573 reaction equation
[C:1]([NH:4][C:5]1[N:9]([C:10]2[C:15]([Cl:16])=[CH:14][C:13]([C:17]([F:20])([F:19])[F:18])=[CH:12][C:11]=2[Cl:21])[N:8]=[C:7]([C:22]#[N:23])[C:6]=1[C:24]#[C:25][Si](C)(C)C)(=[O:3])[CH3:2].C(=O)([O-])[O-].O.CCOCC>CO>[C:1]([NH:4][C:5]1[N:9]([C:10]2[C:15]([Cl:16])=[CH:14][C:13]([C:17]([F:19])([F:20])[F:18])=[CH:12][C:11]=2[Cl:21])[N:8]=[C:7]([C:22]#[N:23])[C:6]=1[C:24]#[CH:25])(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 962WaterHCID 3283Diethyl EtherHCID 19660Carbonate IonHCID 21188091HCID 21188091, compound

Product 1

HCID 21188077HCID 21188077, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 5-acetamido-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)4-trimethylsilylethynylpyrazole (20 mg, the compound of Example B2) in methanol (1 ml) was added potassiun carbonate (20 mg). The reaction mixture was stirred at room temperature for 40 minutes and then poured into water (20 ml) and ether (20 ml). The organic layer was separated, dried (MgSO4) and evaporated. The crude product was purified by column chromatography on silica gel eluted with ether to provide the title compound as a white solid.

Workup

  1. customThe organic layer was separated
  2. dry with materialdried (MgSO4)
  3. customevaporated
  4. customThe crude product was purified by column chromatography on silica gel
  5. washeluted with ether

Sources & evidence

ORD record
ord-a18611f67c584f6c9647768f883a6292
Source dataset
uspto-grants-2001_07
Patent number
US06255333B1

Reaction notes

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