Water → HCID 21188051, compound

Participants

Reaction Steps

To a solution of 3-cyano-5-di-(t-butoxycarbonyl)amino-1-(2,6-dichloro-4-trifluoromethylphenyl)4-ethynylpyrazole (100 mg, the compound of Example B4) in acetone (10 ml) was added silver nitrate (5 mg) and N-bromosuccinimide (80 mg). The mixture was stirred at room temperature for one hour and then poured into ether (100 ml) and water (100 ml). The organic layer was separated, dried (MgSO4) and evaporated. The crude product was purified by column chromatography on silica gel eluted with dichloromethane to provide the title compound as a pale yellow solid m.p. 130-1° C.

Provenance & Evidence