Diethyl Ether → HCID 21188068, compound

Participants

Reaction Steps

To a solution of 3-cyano-5-di-(t-butoxycarbonyl)amino-1-(2,6-dichloro-4-trifluoromethylphenyl)4bromoethynylpyrazole (200 mg, the compound of Example B5) in anhydrous dichloromethane (2 ml) was added dropwise trifluoroacetic acid (0.2 ml). After 30 minutes the reaction mixture was treated with ether (10 ml) and saturated aqueous sodium hydrogen carbonate solution (10 ml). The organic layer was separated, dried (MgSO4) and evaporated to provide the title compound as a white solid m.p. 168-70° C.

Provenance & Evidence