Water → HCID 21188071, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)4-iodo-5-(N-pyrrolyl)pyrazole (0.55 g) in triethylamine (1 ml) and dimethylformamide (10 ml) was added trimethylsilylacetylene (1 ml), cuprous iodide (15 mg) and bis(triphenylphosphine)palladium (II) chloride (30 mg). The reaction mixture was heated at 70° C. for 24 hours, and then poured into water (100 ml) and diethyl ether (100 ml). The organic layer was dried over MgSO4 and the solvent was evaporated. The crude product was purified by chromatography on silica gel (50 g), eluting with dichloromethane: hexane (1:1), giving the title compound as a pale brown solid.

Provenance & Evidence