N-Iodosuccinimide → HCID 22618498, compound

HRID 1383601Notes

Reaction equation

HRID 1383601 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]([F:22])([F:21])[F:20])[CH:3]=1.[I:23]N1C(=O)CCC1=O>C(#N)C>[NH2:1][C:2]1[N:6]([C:7]2[C:8]([Cl:18])=[CH:9][C:10]([C:14]([F:15])([F:16])[F:17])=[CH:11][C:12]=2[Cl:13])[N:5]=[C:4]([C:19]([F:22])([F:21])[F:20])[C:3]=1[I:23]

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 22618376HCID 22618376, compound

Product 1

HCID 22618498HCID 22618498, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a stirred solution of 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-trifluoromethylpyrazole (0.182 g) in acetonitrile (3 ml) at room temperature was added N-iodosuccinimide (0.113 g). After 20 minutes the mixture was evaporated to dryness and the residue taken up in dichloromethane (20 ml). After washing with water (20 ml, ×2), brine (20 ml) and drying (MgSO4) the solution was evaporated. The residue was triturated with hexane and the supernatant evaporated to give the title compound as an off-white solid, m.p. 126° C.

Workup

  1. customAfter 20 minutes the mixture was evaporated to dryness
  2. washAfter washing with water (20 ml, ×2), brine (20 ml)
  3. dry with materialdrying (MgSO4) the solution
  4. customwas evaporated
  5. customThe residue was triturated with hexane
  6. customthe supernatant evaporated

Sources & evidence

ORD record
ord-107fe51eb6b54c58924d9b89d4ae3748
Source dataset
uspto-grants-2001_07
Patent number
US06255333B1

Reaction notes

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