N-bromobutanimide → HCID 21188099, compound

Participants

Reaction Steps

To a stirred solution of 1-(2,6-dichloro-4-trifluoromethylphenyl)4ethynyl-3-trifluoromethylpyrazole (3.1 g) in acetone (25 ml) was added N-bromosuccinimide (1.4 g) and silver nitrate (0. 14 g). Stirring was continued at room temperature for 2 hours. The reaction mixture was evaporated and the residue partitioned between ether and water. The organic layer was separated, dried and evaporated. The residue was purified by column chromatography on silica gel (10 g) eluted with hexane and then dichloromethane: hexane (1:1). Combination and evaporation of appropriate fractions, followed by crystallisation from hexane, gave the title compound as a white solid m.p. 92-94° C.

Provenance & Evidence