N-Iodosuccinimide → HCID 21188049, compound

HRID 1383606Notes

Reaction equation

HRID 1383606 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]1[C:17]([CH3:18])=[CH:16][C:15]([CH3:19])=[N:14]1.[I:20]N1C(=O)CCC1=O>C(#N)C>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]1[C:17]([CH3:18])=[C:16]([I:20])[C:15]([CH3:19])=[N:14]1

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 27410921H-Pyrazole, 1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-3,5-dimethyl-

Product 1

HCID 21188049HCID 21188049, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

To a stirred solution of 1-(2,6-dichloro-4-trifluoromethylphenyl)-3,5-dimethylpyrazole (0.218 g) in acetonitrile (3 ml) at room temperature was added dropwise a solution of N-iodosuccinimide (0.158 g) in acetonitrile (2 ml). After 27 hours the mixture was evaporated to dryness and the residue purified by column chromatography on silica gel (5 g) eluted with dichloromethane. Combination and evaporation of suitable fractions provided the title compound as yellow oil.

Workup

  1. customAfter 27 hours the mixture was evaporated to dryness
  2. customthe residue purified by column chromatography on silica gel (5 g)
  3. washeluted with dichloromethane
  4. customCombination and evaporation of suitable fractions

Sources & evidence

ORD record
ord-fdc1cba34f7949b98cc7facb9ac6dd21
Source dataset
uspto-grants-2001_07
Patent number
US06255333B1

Reaction notes

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