N-Iodosuccinimide → HCID 22618399, compound

HRID 1383608Notes

Reaction equation

HRID 1383608 reaction equation
[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([CH3:19])[CH:3]=1.[I:20]N1C(=O)CCC1=O>C(#N)C>[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:16])([F:15])[F:17])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([CH3:19])[C:3]=1[I:20]

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 14280576HCID 14280576, compound

Product 1

HCID 22618399HCID 22618399, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a stirred solution of 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-methyl pyrazole (9 g) in acetonitrile (200 ml) at room temperature was added N-iodosuccinimide (5.5 g). The mixture was heated under reflux for one hour and then left at room temperature overnight. The mixture was evaporated and the residue was triturated with hot hexane. The precipitate obtained upon cooling was filtered off and dried to give the title compound as an off-white solid, m.p. 116-118° C.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for one hour
  3. customThe mixture was evaporated
  4. customthe residue was triturated with hot hexane
  5. customThe precipitate obtained
  6. temperatureupon cooling
  7. filtrationwas filtered off
  8. customdried

Sources & evidence

ORD record
ord-0ed011ab812648d3bbfcefe569034fbd
Source dataset
uspto-grants-2001_07
Patent number
US06255333B1

Reaction notes

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