1-(4-Fluorophenyl)-2-methylpropan-1-ol → 1-(4-Fluorophenyl)-2-methylpropan-1-one

HRID 1383692Notes

Reaction equation

HRID 1383692 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:12])[CH:9]([CH3:11])[CH3:10])=[CH:4][CH:3]=1.CC(C)=O.OS(O)(=O)=O.O=[Cr](=O)=O>CC(C)=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:12])[CH:9]([CH3:10])[CH3:11])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 104195641-(4-Fluorophenyl)-2-methylpropan-1-olHCID 131709961Jones' reagent

Product 1

HCID 27828291-(4-Fluorophenyl)-2-methylpropan-1-one

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 1-(4-Fluoro-phenyl)-2-methyl-propan-1-ol (1.6 g) in acetone (10 mL) at 0° C. is added Jones reagent (20 mL) with stirring. After 10 minutes excess Jones reagent is destroyed by addition of isopropyl alcohol. Diethyl ether is added followed by anhydrous magnesium and the mixture is filtered and evaporated to give the product, a yellow oil (1.2 g).

Workup

  1. customAfter 10 minutes excess Jones reagent is destroyed by addition of isopropyl alcohol
  2. additionDiethyl ether is added
  3. filtrationthe mixture is filtered
  4. customevaporated
  5. customto give the product

Sources & evidence

ORD record
ord-9a420df5c8754bc8b175d8d868491784
Source dataset
uspto-grants-2001_07
Patent number
US06255349B1

Reaction notes

Loading…