反应详情

A mixture of Z-N-Me-Phg-Tyr(3-tBu)-NH2 (4.03 g) and 10% palladium carbon (2.0 g) in methanol (200 ml) was stirred in a hydrogen atmosphere for 4 hours. The reaction mixture was filtered and the filtrate was distilled off under reduced pressure; the resulting residue was subjected to silica gel column chromatography (eluting solvent consisting of methylene chloride, methanol and aqueous ammonia at a ratio of 100:5:1) to give N-Me-Phg-Tyr(3-tBu)-NH2 in 1.48 g (50%) and N-Me-D-Phg-Tyr(3-tBu)-NH2 in the amount of 920 mg (31%).

1. filtrationThe reaction mixture was filtered
2. distillationthe filtrate was distilled off under reduced pressure
3. washeluting solvent