HCID 131722746, compound → HCID 131722745, compound

Participants

Reaction Steps

To a solution of 188 mg (0.287 mmol) of Z-Phe-Cha-Phe(3-tBu)-NH2 in 3 ml of methanol, 100 mg of 10% palladium carbon was added and the mixture was stirred overnight in a hydrogen atmosphere at room temperature. After filtering, the filtrate was concentrated under reduced pressure and the resulting residue was subjected to silica gel column chromatography (eluting solvent, chloroform:methanol=10:1) to yield Phe-Cha-Phe(3-tBu)-NH2 in the amount of 69.0 mg (46%).

Provenance & Evidence