HCID 21187415, compound → HCID 21187427, compound

Participants

Reaction Steps

To a solution of 132 mg (0.183 mmol) of N-[2-benzoxycarbonylamino-1-[(3-tert-butyl-4-hydroxyphenyl)methyl]ethyl]-2-[[2-(benzoxycarbonylamino)-3-phenylpropyl]amino]-3-methyl butanamide in methanol (2 ml), 10% palladium carbon (80 mg) was added and the mixture was stirred in a hydrogen atmosphere at room temperature for 2 days. After filtering, the filtrate was concentrated under reduced pressure and the resulting residue was subjected to silica gel column chromatography (eluting solvent consisting of chloroform, methanol and aqueous ammonia at a ratio of 10:1:0.1) to yield 2-[(2-amino-3-phenylpropyl)amino]-N-[2-amino-1-[(3-tert-butyl-4-hydroxyphenyl)methyl]ethyl]-3-methyl butanamide in the amount of 24.2 mg (29%).

Provenance & Evidence