N-benzyl-2-(4-benzyloxy-3-tert-butylphenyl)-1-methyl-N-(benzyloxycarbonyl)ethylamine → 2-(3-Tert-butyl-4-hydroxyphenyl)-1-methylethylamine

Participants

Reaction Steps

A suspension of 2.35 g (4.50 mmol) of N-benzyl-2-(4-benzyloxy-3-tert-butylphenyl)-1-methyl-N-(benzyloxycarbonyl)ethylamine and 0.50 g of a 20% palladium hydride on carbon catalyst in methanol (30 ml) was stirred overnight in a hydrogen atmosphere. After filtering off the catalyst, the solvent was distilled off under reduced pressure to give 2-(3-tert-butyl-4-hydroxyphenyl)-1-methylethylamine in the amount of 0.90 g (96%).

Provenance & Evidence