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HRID1383793

反应详情

EQUATION

反应方程式

HRID 1383793 的结构方程式

REACTANTS

反应物

2
结构：CC(O)COC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]8COCC(C)O)O[C@@H]7COCC(C)O)O[C@@H]6COCC(C)O)O[C@@H]5COCC(C)O)O[C@@H]4COCC(C)O)O[C@@H]3COCC(C)O
HCID14049689

6A,6B,6C,6D,6E,6F,6G-Heptakis-O-(2-hydroxypropyl)-β-cyclodextrinr

C63H112O42

2 次

结构：CCCCCCCCCC(=O)[O-].CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
HCID21188875

未命名化合物

2 次

PRODUCTS

生成物

1
结构：CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
HCID5358

Sumatriptan

C14H21N3O2S

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Sumatriptan caprate and hydroxypropyl-beta cyclodextrin (HPB) were complexed by the kneading method. Sumatriptan caprate (1.254 g) and HPB (3.748 g) were blended together. Water (4.5 mL) was added and the mixture ground together in a mortar with a pestle to form a uniform paste. Grinding was continued for 30 minutes. The paste was then dried in a vacuum oven (40° C.; 0 bar) for 48 hours. The solid mass was broken up, passed through a 60 mesh screen and returned to the vacuum oven (40° C.; 0 bar) for 12 hours in order to ensure uniform drying of the complex. Analysis by HPLC for sumatriptan base content, and Karl Fischer for moisture content gave the following results: % sumatriptan base was 16.40% and the moisture content was 3.45%. The complex was characterised by DSC, FT-IR and XRD.

WORKUP

后处理

  1. customthe mixture ground together in a mortar with a pestle to form a uniform paste
  2. customGrinding
  3. customThe paste was then dried in a vacuum oven (40° C.; 0 bar) for 48 hours
  4. waitreturned to the vacuum oven (40° C.; 0 bar) for 12 hours in order
  5. customto ensure uniform drying of the complex