p-Toluenesulfonic acid → HCID 66660252, compound

Participants

Reaction Steps

This compound was prepared from 3,6-dichloro-4-(furan-2-yl)-pyridazine (Example 140 part a) using the procedures described in Example 16 Steps b) and c) except 1.1 equivalents of triethylamine hydrochloride was used in Step b) instead of 1.1 equivalents of p-toluenesulphonic acid and triethylamine, and (1-methyl-1 H-1,2,4-triazol-3yl)methanol (Example 65) was used in Step c) instead of 2-pyridylcarbinol. Data for the title compound: m.p. 257-259° C. (DMF). 1H NMR (360 MHz, d6-DMSO) 3.91 (3 H s), 5.63 (2 H, s), 6.74 (1 H, dd, J=4 and 2 Hz), 7.33 (1 H, d, J=4 Hz), 7.54-7.65 (3 H, m), 7.99 (1 H, d, J=2 Hz), 8.44 (1 H, s), 8.46 (2 H, d, J=7 Hz), 8.57 (1 H, s). MS (ES+) 374 [MH]+. Anal. Found C, 60.68; H 4.11; N, 25.82. C19H15N7O2. 0.15 H2O requires C, 60.68; H, 4.10; N, 26.07%.

Provenance & Evidence