Sodium Hydroxide → HCID 21187525, compound

Participants

Reaction Steps

6-Chloro-7-cyclobutyl-3-phenyl-1,2,4-triazolo[4,3-b]pyridazine (2.0 g, 7.0 mmol), 2 N NaOH (50 ml) and 1,4-dioxane (10 ml) were heated at reflux for 16 hours. Cooled and water (150 ml) added. Precipitate filtered, suspended in H2O, acidified (2 N HCl), filtered and dried to give a white solid. 1H NMR (250 MHz, CDCl3) δ1.89-2.02 (1 H, m), 2.08-2.25 (3 H, m), 2.36-2.48 (1 H, m), 3.56-3.70 (1 H, m), 7.48-7.60 (3 H, m), 7.88 (1 H, s), 8.38 (1 H, m). Mass spec ES+ (M+1)=267.

Provenance & Evidence