Potassium Carbonate → HCID 131722755, compound

Participants

Reaction Steps

Potassium carbonate (311 mg, 2.2 mmol) and 1,4 dichloro-2-butyne (275 mg, 2.2 mol) in DMF (3 ml) were heated to 50° C. prior to the dropwise addition of the product from Example 185, Step a (200 mg, 0.75 mmol) in DMF (2 ml). The reaction mixture was left to stir for 2 hours. Cooled and partitioned (ethyl acetate/water). The organic layer was washed (H2O, brine), dried MgSO4) and evaporated in vacuo. Purified via silica gel chromatography using 50/50 ethyl acetate/hexane to elute. 1H NMR (250 MHz, CDCl3) δ1.93 (1 H, m), 2.11-2.16 (3 H, m), 2.42 (2 H, m), 4.2 (2 H, m), 5.10 (2 H, m), 7.50-7.59 (3 H, m), 7.84 (1 H, s), 8.47 (2 H, m).

Provenance & Evidence