Sodium ion → 6-[({trans-4-[2-(6-Methoxy-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)ethyl]cyclohexyl}amino)methyl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one

HRID 138386Notes

Reaction equation

HRID 138386 reaction equation
[C:36]([BH3-:37])#[N:38].[NH2:1][CH:2]1[CH2:3][CH2:4][CH:5]([CH2:8][CH2:9][N:10]2[C:11](=[O:22])[CH2:12][O:13][c:14]3[c:15]2[cH:16][c:17]([O:20][CH3:21])[cH:18][cH:19]3)[CH2:6][CH2:7]1.[Na+:39].[O:23]=[C:24]1[NH:25][c:26]2[c:27]([cH:30][cH:31][c:32]([CH:34]=[O:35])[n:33]2)[O:28][CH2:29]1>>[NH:1]([CH:2]1[CH2:3][CH2:4][CH:5]([CH2:8][CH2:9][N:10]2[C:11](=[O:22])[CH2:12][O:13][c:14]3[c:15]2[cH:16][c:17]([O:20][CH3:21])[cH:18][cH:19]3)[CH2:6][CH2:7]1)[CH2:34][c:32]1[cH:31][cH:30][c:27]2[c:26]([n:33]1)[NH:25][C:24](=[O:23])[CH2:29][O:28]2

Participants

5

Reactant 4

HCID 923Sodium ionHCID 498716Cyano-borohydrideHCID 218737373-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carbaldehydeHCID 667744114-[2-(Trans-4-aminocyclohexyl)ethyl]-6-methoxy-2H-1,4-benzoxazin-3(4H)-one

Product 1

HCID 159838136-[({trans-4-[2-(6-Methoxy-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)ethyl]cyclohexyl}amino)methyl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one

Sources & evidence

ORD record
ord-0a731b2dd91742a2bd968ff9760eb806
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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