Piconol → HCID 57438969, compound

Participants

Reaction Steps

The compound was prepared using the procedures described in Example 102, Steps a), b) and c) with 1-methylcyclobutane carboxylic acid (U.S. Pat. No. 4,220,795) and 3,6-dichloro-4-methylpyridazine being used instead of cyclopentane carboxylic acid and 3,6-dichloropyridazine respectively in Step a), and benzoic acid hydrazide being used instead of 2-thiophene carboxylic acid hydrazide in Step b), and (1-methyl-1 H-1,2,4-triazol-3-yl)methanol (prepared using the conditions described in EP-A-421210) being used instead of 2-hydroxymethylpyridine in Step c). Data for the title compound: 1H NMR (360 MHz, CDCl3) δ1.57 (3 H, s), 1.74-1.84 (1 H, m), 2.02-2.14 (1 H, m), 2.20-2.26 (2 H, m), 2.50-2.58 (2 H, m), 2.62 (3 H, s), 3.93 (3 H, s), 5.48 (2 H, s), 7.44-7.54 (3 H, m), 8.04 (1 H, s), 8.49 (2 H, d, J=8 Hz); MS (ES+) m/e 390 [MH]+. Anal. Found C, 64.74; H, 5.92; N, 24.88. C21H23N7O requires C, 64.76; H, 5.95; N, 25.18%.

Provenance & Evidence