Piconol → HCID 22457794、化合物

関与物質

反応手順

The compound was prepared using the procedures described in Example 102, Steps a), b) and c) with 1-methylcyclobutane carboxylic acid (U.S. Pat. No. 4,220,795) and 3,6-dichloro-4-methylpyridazine being used instead of cyclopentane carboxylic acid and 3,6-dichloropyridazine respectively in Step a), and benzoic acid hydrazide being used instead of 2-thiophene carboxylic acid hydrazide in Step b), and (2-methyl-2 H-1,2,4-triazol-3-yl)methanol (prepared using the conditions described in EP-A-421210) being used instead of 2-hydroxymethylpyridine in Step c). Data for the title compound: 1H NMR (360 MHz, CDCl3) δ1.54 (3 H, s), 1.76-1.84 (1 H, m), 2.04-2.16 (3 H, m), 2.46-2.53 (2 H, m), 2.64 (3 H, s), 3.94 (3 H, s), 5.53 (2 H, s), 7.46-7.56 (3 H, m), 7.93 (1 H, s), 8.34 (2 H, d, J=8 Hz); MS (ES+) m/e 390 [MH]+. Anal. Found C, 64.83; H, 5.82; N, 25.04. C21H23N7O requires C, 64.76; H, 5.95; N, 25.18%.

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