HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1383872Generated: November 1, 2026
Hydrochloric Acid → 1,1-Dimethylethyl N-((1S,2S)-3-chloro-2-hydroxy-1-(phenylmethyl)propyl)carbamate
https://huagongshe.com/reaction/1383872
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl N-((2S)-4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate | HCID 9926241 | — |
| Product | 1,1-Dimethylethyl N-((1S,2S)-3-chloro-2-hydroxy-1-(phenylmethyl)propyl)carbamate | HCID 7146645 | — |
Reaction Steps
To the thus-prepared reducing agent was added 299 mg (1.0 mmol) of [1(S)-benzyl-2-oxo-3-chloropropyl]carbamic acid t-butyl ester, and the mixture was stirred at 25° C. for 16 hours. After hydrolysis with 1 N hydrochloric acid, the reaction mixture was extracted with ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06255522B1 |
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| Source dataset | uspto-grants-2001_07 |
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| ORD ID | ord-62969f56f32544ee89d711f4c33014a4 |
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| Source note | uspto-grants-2001_07 |
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