4-[4-[2-(N-dodecyl-N-methylamino)ethoxy]phenyl]1,1,1-trifluoro-2-butanone → 4-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]-2-vinylphenyl]-1,1,1-trifluoro-2-butanone

HRID 1383906Notes

Reaction equation

HRID 1383906 reaction equation
Cl.[CH2:2]([N:14]([CH2:16][CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27]([OH:29])=O)=[C:21]([CH:30]=[CH2:31])[CH:20]=1)[CH3:15])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].C(N(CCOC1C=CC(CCC(=O)[C:58]([F:61])([F:60])[F:59])=CC=1)C)CCCCCCCCCCC>>[CH2:2]([N:14]([CH2:16][CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][C:27](=[O:29])[C:58]([F:61])([F:60])[F:59])=[C:21]([CH:30]=[CH2:31])[CH:20]=1)[CH3:15])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

Participants

3

Reactant 2

HCID 99550834-[4-[2-(N-dodecyl-N-methylamino)ethoxy]phenyl]1,1,1-trifluoro-2-butanoneHCID 1317227603-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]-2-vinylphenyl]propanoic acid, hydrochloride

Product 1

HCID 183190774-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]-2-vinylphenyl]-1,1,1-trifluoro-2-butanoneYield 54%

Procedure

3-[4-[2-(N-Dodecyl-N-methylamino)ethoxy]-2-vinylphenyl]propanoic acid, hydrochloride (830 mg, 1.83 mmol) was reacted by the general procedure as described in the preparation of 4-[4-[2-(N-dodecyl-N-methylamino)ethoxy]phenyl]-1,1,1-trifluoro-2-butanone. The residue was chromatographed on silica gel (ethyl acetate) to afforded the title compound (0.46 g, 54%) as a pale purple oil.

Workup

  1. customThe residue was chromatographed on silica gel (ethyl acetate)

Sources & evidence

ORD record
ord-87f5db84e04f45179a32293b4f358f37
Source dataset
uspto-grants-2001_07
Patent number
US06255496B1

Reaction notes

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