HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[N-Dodecyl-N-2-[4-[3-hydroxy-4,4,4-trifluorobutyl]phenoxy]ethylamino]butanoic acid, ethyl ester → 3[N-Dodecyl-N-2-[4-[3hydroxy4,4,4-trifluorobutyl]phenoxy]ethylamino]propanoic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[N-Dodecyl-N-2-[4-[3-hydroxy-4,4,4-trifluorobutyl]phenoxy]ethylamino]butanoic acid, ethyl ester | HCID 86757123 | — |
| Reactant | [N-dodecyl-N-2-[4-(E)-[3-hydroxy-4,4,4-trifluorobut-1-en-1-yl]phenoxy]ethylamino]propanoic acid, ethyl ester | HCID 86757127 | — |
| Product | 3[N-Dodecyl-N-2-[4-[3hydroxy4,4,4-trifluorobutyl]phenoxy]ethylamino]propanoic acid, ethyl ester | HCID 86757126 | 92% |
Reaction Steps
[N-dodecyl-N-2-[4-(E)-[3-hydroxy-4,4,4-trifluorobut-1-en-1-yl]phenoxy]ethylamino]propanoic acid, ethyl ester (620 mg, 1.17 mmol) was hydrogenated as described in the preparation of 4-[N-dodecyl-N-2-[4-[3-hydroxy-4,4,4-trifluorobutyl]phenoxy]ethylamino]butanoic acid, ethyl ester (Example 48) and afforded the title compound (573 mg, 92%) as a clear oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06255496B1 |
| Source dataset | uspto-grants-2001_07 |
| ORD ID | ord-856dd096c5034849aa578c2227f01e34 |
| Source note | uspto-grants-2001_07 |